Published on April 26, 2021

Krill Oil vs Fish Oil: Which Should You Take?

Krill Oil vs Fish Oil: Which Should You Take?

Omega 3 fats are essential in our diet, and there are lots of different sources, such as oily fish, nuts, seeds, and also supplements. There are pros and cons of both food sources and also supplements. So, in this article, I will guide you through the advantages and disadvantages of Krill oil vs fish oil supplements. I’ll also cover who needs to take these supplements, and if krill oil is better than fish oil, and cod liver oil.

What Are Omega Fatty Acids?

There are two types of fats or fatty acids that are essential and can’t be produced in our bodies. These are omega 3 and omega 6. Omega 3 can be broken down into three main forms: alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

Where Are Omega Fatty Acids Found?

ALA is found in plant oils, such as flaxseed, soybean, and canola oils. DHA and EPA are found in oily fish, fish oils, and krill oils. DHA and EPA are actually synthesized by microalgae—not by the fish—but accumulate in the tissue when they are eaten by fish and shellfish further up the food chain.

Why Are Omega Fatty Acids So Important?

Omega-3 and -6 fatty acids have an important structural role needed for cell membranes. They are also energy sources and are used to form signaling molecules called eicosanoids, comprised of prostaglandins, thromboxanes, and leukotrienes.

There are many different prostaglandins with wide-ranging roles, such as the sensation of pain, inflammation, regulation of pregnancy and birth, control of blood pressure, secretion of stomach acid, contraction, and relaxation of smooth muscle.

Thromboxanes regulate blood clotting by causing constriction of blood vessels and the aggregation of platelets (so they stick together), which are early steps in blood clotting.

Leukotrienes are involved in immune function by attracting immune cells such as neutrophils to sites of inflammation. They also constrict bronchioles in the lungs and make capillary walls permeable.


This is thought to be because the metabolic products of omega-3 fatty acids are less inflammatory than those produced from omega 6 fatty acids. Western diets are associated with an imbalance of omega-3, -6 such that instead of levels of omega 3 being higher than 6, the reverse is more commonly seen. This is associated with an increased risk of chronic inflammation.[1]

A large systemic review that combined 86 trials involving over 162,000 people looked at the effect of higher omega-3 intake versus lower omega-3 intake for at least a year. This was provided mostly by omega-3 supplements while a few trials gave oily fish. Omega-3 fatty acids have been shown to reduce blood pressure and can be incorporated into your diet by eating oily fish or seeds, such as chia seeds, flax seeds, and nuts.[2]

There are three types of omega-3: those found in oily fish called EPA and DHA and the plant-based ALA.

What Is Krill Oil?

Krill oil is extracted from the bodies of Antarctic krill, a tiny shrimp-like shellfish. Krill oil, fish oil, and cod liver oil are similar in that they all contain DHA and EPA.

Fish oil is extracted from the body of the fish and contains some vitamin A and vitamin D as well. Cod liver oil is extracted from the liver of the fish and contains higher levels of vitamin A and D.

High doses of vitamin A can be toxic as it is a fat-soluble vitamin that is stored by your body. This is why omega 3 supplements that contain vitamin A are to be avoided in pregnancy because high levels of this vitamin may damage the fetus.

Krill Oil Vs Fish Oil

Evidence surrounding krill oil is limited compared with fish oils and cod liver oils. A large portion of the EPA and DHA in krill comes in phospholipid form (whereas fish oil fatty acids are contained in triacylglycerols), which some claim has a higher rate of absorption in the body than fish oil.


Previously, it was thought that Krill oil was more bioavailable than fish oil, but there were problems with this research with regards to dosing.[3] More recently, a randomized controlled trial in 66 people was performed to answer this question and compared the bioavailability of krill oil compared with fish oil. It found that there was no difference between blood measurements of DHA and EPA. Therefore, the evidence does not support krill oil being “better” or needing lower doses than fish oil.[4]

Krill Oil Vs Fish Oil in Terms of Cholesterol

A study in animals looked at gene expression after supplementation with either krill oil or fish oil. They found that fish oil upregulated (increased gene expression) the cholesterol synthesis pathway more than krill oil. Krill oil was found to upregulate (increase gene expression) more metabolic pathways than fish oil. This suggests that there might be different biological effects between krill and fish oil but more research is needed.[5]

In group (meta) analysis of seven trials totaling 662 participants, Krill oil supplementation was found to reduce low-density lipoprotein cholesterol and triglycerides but not total cholesterol.[6] Whether this translates to decreased risk of cardiovascular disease needs further research.

However, when directly compared, krill oil was not superior to fish oil supplementation and had very similar effects on cholesterol.[7]

Krill Oil Vs Cod Liver Oil

Cod liver oil contains higher levels of vitamin D and vitamin A, which may be toxic in excess. If you want to take a high dose of omega-3, this means you will also end up having higher doses of vitamin A and D. Both of these are fat-soluble vitamins that are stored by the body and can become toxic. Vitamin A supplementation should be avoided during pregnancy due to risks for the baby.

There is a risk that since the liver is used to filter out toxins, there is the possibility that cod liver oil contains more environmental contaminants than fish oil or krill oil.

Are There Risks With Krill Oil?

Less research has been performed on krill oil and although no side effects have been reported, the safe maximum dose of natural astaxanthin has not been determined.


Krill make up a vital part of the Antarctic food chain and a huge number of species higher up the food chain depend on them. Fishing krill has the potential to catastrophically destabilize this important food chain. Therefore, fish oils are more sustainable than krill oil.

Why Is Krill Oil Red?

The deep red color of krill oil is due to a compound called astaxanthin found in krill. Astaxanthin is also found in other more sustainable sources such as red trout, crab, lobster, and wild salmon. Astaxanthin is a carotenoid antioxidant compound that mops up harmful free radicals.

When to Take Omega-3 Supplement

A large review of 86 trials combined—totaling over 162,000 people—looked to see what the effect of increased omega-3 had on cardiovascular risk. Increasing ALA made no significant difference to blood clots of the coronary arteries supplying the heart (coronary events) but slightly reduced cardiovascular events (diseases related to blood vessels such as clots and rhythm problems) while EPA and DHA reduced serum triglycerides and also reduced the risk of coronary heart disease, such as heart attacks.[8]

They found that EPA and DHA decreased triglycerides (a type of fat) by about 15% and reduced the risk of coronary artery death and coronary events, which are illnesses of arteries supplying the heart. However, they did not affect cardiovascular events (e.g., strokes, heart irregularities).[9]

While increasing ALA made no significant difference to coronary events, it slightly reduced cardiovascular events. This means that the three combined (ALA, EPA, and DHA combined) may reduce the risk of coronary, cardiovascular disease, and lower triglyceride levels, but the effects are small.

One of the ways of decreasing your risk of cardiovascular disease is by lowering your cholesterol—reducing saturated fats in your diet and eating ALA omega-3 (e.g., from walnuts). A grouped meta-analysis has not found any link between omega-3 and dementia, but more information is needed to see if omega-3 can prevent cognitive decline.[10]

Overall, if you aren’t pregnant or intending to get pregnant, then omega 3 supplements are probably unlikely to do you harm and might benefit your long-term cardiovascular risk. It isn’t possible to tell the difference in general between eating enough omega-3 in your diet versus supplementing, but whole foods have other benefits as well.


Omega-3 supplements often have high levels of vitamin A, which can be harmful in pregnancy. Therefore, you should avoid supplementing or choose a pregnancy-safe version.

If you are vegan, you may consider taking an omega-3 supplement made from algae or seaweed, but these are unregulated and can contain significant quantities of iodine, which can be harmful. Therefore, it is better, where possible, to optimize your diet. There are concerns that part of the benefit of omega-3 is from a whole food effect that isn’t seen with taking a supplement instead.

Tips on How to Get Enough Omega-3 in Your Diet

  • Aim to have oily fish twice a week if you aren’t pregnant or once a week if you are, as the benefit of omega-3 has to be offset by the risk of contamination with heavy metals.
  • Algae and seaweed are the only plant-based sources of EPA and DHA, but ALA can be converted in your body into EPA and DHA.
  • Vegan sources of omega-3 are chia seeds, linseed, hemp seeds, walnuts, and vegetable oils, such as rapeseed. To meet the current guidance for omega-3, you would need to eat about a tablespoon of chia or ground linseeds, or two tablespoons of hemp seeds, or six walnut halves a day.
  • Algae oil is an alternative to fish oil, which makes it an attractive option for vegetarians. But while algae oils do contain large amounts of DHA, most don’t contain any EPA fatty acids at all.

In Summary

Krill oil supplements appear to be safe and as effective as fish oil. They also have the bonus of containing the antioxidant astaxanthin.

However, harvesting krill is not sustainable, and there are risks regarding destabilizing the Antarctic food chain. Instead, aim to include foods rich in omega-3 in your diet to benefit from the “whole food effect,” and eat foods that are naturally rich in carotenoids, such as vegetables, crab, and lobster. Avoid taking high doses of cod liver oil, and avoid it completely during pregnancy due to the risk of vitamin A.

Featured photo credit: Anshu A via


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Dr. Harriet Holme

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Published on June 15, 2021

13 Health Benefits Of Omega 3 Fatty Acids (Backed By Science)

13 Health Benefits Of Omega 3 Fatty Acids (Backed By Science)

Omega-3 fatty acids are a type of fat that the body requires for survival but is unable to produce on its own. It is, therefore, extremely important to get enough of these vital nutrients in your diet. There are three different types of Omega-3s. The first two types, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found mainly in fish. The third type, alpha-linolenic acid (ALA) is found in plant sources.[1]

Foods that are high in Omega-3 fatty acids include fish, such as salmon, mackerel, and herring. Plant sources of Omega-3s include flaxseeds, chia seeds, walnuts, and canola oil.[2] Fish oil supplements, commonly found in the grocery store, are also great sources of Omega-3 fatty acids for those who don’t like to eat any of these foods.

While most of us have heard of Omega-3 fatty acids before, their specific health benefits are not commonly known. There are so many incredible reasons to include Omega-3 fatty acids in your diet. In this article, I’ll review many of the major Omega-3 health benefits you can expect from adding them into your diet.

1. Reduced Risk of Cardiovascular Disease

Eating Omega-3 fatty acids in foods such as fish or nuts can lead to a reduced risk of cardiovascular or heart disease. They do this by lowering triglyceride levels in the bloodstream. Triglycerides are a type of fat that occurs in the body and is the main contributor to body fat.[3]

2. Reduced Risk of Blood Clots

According to the Centers for Disease Control and Prevention (CDC), as many as 900,000 people could be affected by blood clots each year in the United States.[4] Having a diet rich in Omega-3s helps to prevent platelets in the blood from clumping together, which reduces the risk of blood clots.[5]


3. Reduced Blood Pressure

Another Omega-3 health benefit is blood pressure reduction. High blood pressure is common among individuals in the United States, in large part due to dietary patterns. In a study conducted in Europe, consuming fish rich in Omega-3 such as salmon three times per week was shown to decrease diastolic blood pressure.[6]

4. Reduced Cholesterol

Along with high blood pressure, many individuals across the globe struggle with high cholesterol. It’s important to keep your cholesterol levels down as cholesterol is the building block for plaque formation in your arteries. Studies show that increased intakes of Omega-3s can lead to overall reduced cholesterol.[7]

5. Reduced Plaque in Your Arteries

As mentioned above, plaque formation in the arteries is caused by cholesterol in the blood. This plaque can cause a clot, which may lead to a heart attack.[8] Therefore, it’s extremely important to prevent plaque buildup as much as possible. Studies show that consumption of Omega-3s can help reduce plaque formation in your arteries, reducing the risk of a heart attack.[9]

6. Reduced Risk of Sudden Cardiac Death

Two main causes of sudden cardiac death are severe ventricular fibrillation or terminal cardiac arrhythmia. Ventricular fibrillation occurs when, instead of pumping blood to the rest of your body, some of the chambers in your heart just quiver. This causes blood pressure to become too low and prevents blood from being delivered to your other organs.[10]

Moreover, a cardiac arrhythmia occurs when the heart pumps irregularly. This could mean that the heart is pumping either too fast or too slow.[11] Studies show that the risk of sudden cardiac death due to either of these causes decrease with increased levels of Omega-3s.[12]


7. Improved Rheumatoid Arthritis Symptoms

Another important Omega-3 health benefit is improved rheumatoid arthritis symptoms. According to the CDC, between 2013-2015, about 23% of the US population was diagnosed with some form of arthritis.[13] This disease is chronic and painful. However, there may be some relief found in changing your diet.

A study published in the American Family Physician Journal showed that increased intakes of Omega-3 fatty acids can reduce inflammation in the body, leading to less stiffness and reduced tenderness in joints.[14]

8. Reduced Risk of Glaucoma

Glaucoma, which the Mayo Clinic defines as a “group of eye conditions that damage the optic nerve,” is one of the leading causes of blindness for older adults.[15] This damage is often caused by increased intraocular pressure (IOP).

Studies showed that increased intakes of Omega-3s reduced intraocular pressure.[16] This indicates that increased intakes of Omega-3 fatty acids may help to prevent glaucoma later in life.

9. Reduced Risk of Cancer

Researchers have recently been studying the benefits of Omega-3 intakes on cancer prevention. Promising data from some studies has shown a reduced risk of colon cancer with increased Omega-3 intakes. Other studies on breast and prostate cancer have more mixed results.[17]


10. Reduced Risk of Mental Health Disorders

Omega-3 fatty acids are extremely important in brain development. Given this information, researchers have been looking into the association between Omega-3 intakes and mental health disorders. In one study, Omega-3 fatty acid supplementation reduced the risk of progression to a psychiatric disorder in individuals who were already at risk of developing one.[18]

Additional studies found that, in those individuals who already had Bipolar Disorder or Tardive Dyskinesia, supplementation with Omega-3 fatty acids reduced symptoms. This was also the case for individuals with Schizophrenia when supplemented with EPA specifically.[19]

In 2017, according to the National Institute of Mental Health, 7.1% of all adults in the United States had at least one major depressive episode.[20] One study published in the Journal of Clinical Psychology found that individuals with depression had lower levels of Omega-3 fatty acids. Additionally, multiple studies found that intakes of Omega-3 fatty acids may improve symptoms of depression in the short term.[21][22]

11. Improvement in Infant Brain Health

Another significant Omega-3 benefit is that it improves infant brain health. One of the three types of Omega-3 fatty acids, DHA, is known to be important in the development of the nervous system. During pregnancy, the fetus relies on the mother’s supply of DHA for brain development.

Studies show that DHA supplementation during pregnancy has been shown to promote higher intelligence in the early years of a baby’s life. A mother eating enough DHA is, therefore, extremely important for the brain development of the child.[23]


12. Reduced Risk of Diabetes

According to a study published in 2020, 15 people out of every 1,000 across the world have type I diabetes.[24] As a disease that is both difficult to manage and costly, it’s important for those who are pregnant to evaluate their diet to prevent their newborn from developing this disease. One change expecting mothers may want to make is adding more canola oil or salmon. Studies showed that increased intakes of Omega-3s in the first year of life led to decreased risk of type 1 diabetes.[25]

13. Weight Reduction

According to the CDC, from 2017 to 2018, 42.4% of Americans were categorized as obese. Additionally, 9.2% of the population of the US were categorized as severely obese.[26] Having a body mass index or BMI that falls within the obese or severely obese categories can also lead to other chronic illnesses, such as heart disease or diabetes. Therefore, it’s extremely important to maintain a healthy weight.

Some studies have found that consuming Omega-3 supplements, along with consuming a healthy diet, improved body composition and reduced cardiovascular risk factors of participants.[27] Another study conducted found that, in overweight men, including fish oils as part of a healthy, calorie-restricted diet led to more weight loss over a 4 week period than did the diet alone.[28]

The Bottom Line

Including Omega-3 fatty acids in your diet clearly has many incredible benefits. From weight loss to improved cardiovascular and brain health to reduced risk of type I diabetes and glaucoma, the Omega-3 health benefits are endless.

If you’re thinking about adding some Omega-3 containing foods into your diet, we’re right there with you! But how much of these healthy fats should you be eating? For an individual without any history of heart disease, The American Heart Association recommends having two servings (6-8 oz) of Omega-3 containing fish each week. If you do have heart disease or high triglyceride levels, check with your doctor regarding serving sizes.[29]


More About Omega-3 Benefits

Featured photo credit: Didssph via


[1] Harvard School of Public Health: Omega-3 Fatty Acids: An Essential Contribution
[2] Cleveland Clinic: Omega-3 Fatty Acids
[3] WebMD: The Facts on Omega-3 Fatty Acids
[4] Centers for Disease Control and Prevention: Data and Statistics on Venous Thromboembolism
[5] Cleveland Clinic: Omega-3 Fatty Acids
[6] Moderate consumption of fatty fish reduces diastolic blood pressure in overweight and obese European young adults during energy restriction
[7] ResearchGate: Omega-3 fatty acids in health and disease and growth and development
[8] Harvard Health Publishing: Can we reduce vascular plaque buildup?
[9] Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials
[10] Mayo Clinic: Ventricular fibrillation
[11] Mayo Clinic: Heart arrhythmia
[12] ResearchGate: Omega-3 fatty acids in health and disease and growth and development
[13] Centers for Disease Control and Prevention: Arthritis-Related Statistics
[14] American Family Physician: Omega-3 Fatty Acids
[15] Mayo Clinic: Glaucoma
[16] TVST: Oral Omega-3 Supplementation Lowers Intraocular Pressure in Normotensive Adults
[17] Dietary fatty acids and colorectal cancer: a case-control study
[18] Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial
[19] Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial
[20] National Institute of Mental Health: Major Depression
[21] ScienceDirect: Omega-3 fatty acids in major depressive disorder: A preliminary double-blind, placebo-controlled trial
[22] ScienceDirect: Short-term supplementation of acute long-chain omega-3 polyunsaturated fatty acids may alter depression status and decrease symptomology among young adults with depression: A preliminary randomized and placebo-controlled trial
[23] Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children’s IQ at 4 years of age
[24] NCBI: Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis
[25] Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study
[26] Centers for Disease Control and Prevention: Adult Obesity Facts
[27] Combining fish-oil supplements with regular aerobic exercise improves body composition and cardiovascular disease risk factors
[28] Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content
[29] Cleveland Clinic: Omega-3 Fatty Acids

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