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Persistent Depression Damages Cognitive Functions, Study Concludes

Persistent Depression Damages Cognitive Functions, Study Concludes

A global study involving 9,000 people has found that persistent and recurring depression can lead to a shrinking of one key area of the brain. This zone is known as the hippocampus (Greek for seahorse) and it does indeed look like one.

This is the area which helps us store long term memories and plays an essential role in connecting our emotions to memories, personality, and consciousness. It can also help us with spatial navigation. It is one of the first areas of the brain to be affected by Alzheimer’s and explains why recent memories are such a big problem for those affected.

Research details

The depression research project involved 15 institutes from all over the world. Researchers compared people possessing normal hippocampi with those who were suffering from persistent depression. This was the largest comparative study of brain volumes ever carried out. The results showed that people who had no treatment for depression (or had recurring episodes over long periods) ended up with a smaller hippocampus.

Researchers used brain magnetic resonance imaging (MRI) and this clearly showed that two thirds of the depressed patients who had recurrences over long periods of time were the ones who had a smaller hippocampus.

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“The more episodes of depression a person had, the greater the reduction in hippocampus size.” – Prof. Ian Hickie, co-director of the research project

What are the implications for the treatment of depression?

First, the good news is that treatment with anti-depressants may help to preserve the size of the hippocampus. There are a wide variety of these drugs available, including Selective Serotonin Reuptake Inhibitors, or SSRIs, which help to balance serotonin and can improve mood. Other popular medications include tricyclic antidepressants.

Of course, it must be remembered that all anti-depressants are required by the FDA to carry a black box warning of possible suicidal thoughts. This usually occurs at the beginning of treatment in teens and young adults or if a drug or dosage is changed.

“There is a lot of nonsense said about antidepressants that constantly perpetuates the evils of them, but there is a good bit of evidence that they have a protective effect.”- Prof. Ian Hickie.

Experts are now convinced that medication in treating depression is just one of the many alternatives available.

Why talk therapy is a valid alternative

Talk therapy is another possible treatment for depression, with various types that can suit individual needs. The chance to talk about depression without being judged, misunderstood or even criticized cannot be overestimated. It is a great way to approach problems and possible ways of solving them. Most medications can never do that quite as effectively.

Additionally, there is a wide range of supplements and lifestyle changes which can help a patient to maintain balance and prevent relapses. These can range from exercise which helps the brain to rewire itself in positive ways to dietary and mindfulness routines.

Research presents no conclusive results regardging the use of supplements but it seems that fish oil, SAMe and folic acid hold out some promise.

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“There’s promising evidence for certain supplements for depression. But more research needs to be done before we’ll know for sure.” – Dr. Ian Cook, Director of the Depression Research Program at UCLA.

The way forward

Depression is still not fully understood. We know that certain areas of the brain such as the hippocampus are involved, but experts are not sure how they all interlink and what mechanisms are at work.

“Despite intensive research aimed at identifying brain structures linked to depression in recent decades, our understanding of what causes depression is still rudimentary.”- Prof. Jim Lagapoulos, co-author of the research project, Brain and Mind Research Institute, University of Sydney.

One thing is certain. We have learned from the research on the hippocampus that lack of treatment or recurring depression are affecting the brain. Processing emotions and memories are at risk. That sends a very clear message — there may be other areas of the brain affected which may have more serious consequences. But this damage is in many cases also reversible.

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This is why we can never ignore depression and always seek treatment when or if it should happen to us or our loved ones.

Featured photo credit: Sigh, Clouds, Rain, Sigh, Iceland via flickr.com

More by this author

Robert Locke

Author of Ziger the Tiger Stories, a health enthusiast specializing in relationships, life improvement and mental health.

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Last Updated on July 12, 2021

100 Incredible Life Hacks That Make Life So Much Easier

100 Incredible Life Hacks That Make Life So Much Easier

Want to learn some quick and easy life hacks that are easy to do, low cost and saves you time?

By tweaking little things in your daily life, it can make your life much more convenient!

Here’re 100 of the most practical life hacks so you can just pick up any of them right away!

83 tie a small piece of bright colored fabric

    84 write random letter

      85 use a rubberband

        86 dorm smell bad

          87 lean your phone on your sunglassess

            89 how to waterproof your shoes

              90 take a picture of the name card

                91 iron inside out

                  92 old newspaper

                    93 tumble try shoes

                      keep a card like this

                        SONY DSC

                          94 soap bar

                            95 make a hole

                              96 drop the battery

                                97 use a coozie

                                  98 when taking a picture

                                    use a clean dust pan

                                      try a pants hanger

                                        use your cellphone light

                                          use a spring from an old pen

                                            quick and easy iphone speaker

                                              user binder clips

                                                wrap a wet paper towel around your beverage

                                                  put pancake mix in a ketchup bottle

                                                    clean out an old lotion bottle for your beach

                                                      use a muffin tin to serve condiments at a bbq

                                                        doritos are great for kindling

                                                          use nail polish to identify different keys

                                                            use a hanging shoe rack to store cleaning supplies

                                                              freeze grapes to chill white wine without

                                                                use paper clips to organize your cables

                                                                  almost finished your jar of nutella

                                                                    sick of having a box full of tangled

                                                                      unroll the rim to increase the capacity

                                                                        cut open toilet paper rolls and use as a cuff

                                                                          remove the stem from strawberries

                                                                            turn an old bottle into a simple little cord holder

                                                                              for iced coffee and iced cappuccino, use frozen coffee cubes

                                                                                how to fold a fitted bed sheet

                                                                                  tired of snoozing past your alarm

                                                                                    place a rubber band around an open paint can to wipe your brush on

                                                                                      ut a wooden spoon across a boiling pot

                                                                                        use bread clips to save flip-flops

                                                                                          take pictures of friends holding items

                                                                                            how i always know which headphone is the left one

                                                                                              put a stocking over the end of a vacuum

                                                                                                How to make sure you drink enough water

                                                                                                  user a can opener to open blister

                                                                                                    good sandwich guide

                                                                                                      turn your muffin pans upside down

                                                                                                        50 pounds of groceries and living on the 5th floor

                                                                                                          the right way to make a blt

                                                                                                            add one teaspoon of baking soda

                                                                                                              38

                                                                                                                hair straighteners equals to collar irons

                                                                                                                  stack your clothes vertically to see them all

                                                                                                                    the right way to make cookies in the summer

                                                                                                                      how to clean a blender

                                                                                                                        the right way to eat a popsicle

                                                                                                                          use bread clips to label and organize power cords

                                                                                                                            to get the built up residue off of your shower head

                                                                                                                              user a hair clip to orgainize long wires

                                                                                                                                a frozen saturated sponge in a bag

                                                                                                                                  rub stuck zipper teeth with a graphite pencil

                                                                                                                                    use a soda pop tab

                                                                                                                                      50

                                                                                                                                        51 How to multiply large numbers in your head.

                                                                                                                                          52 How to open a bottle if you dont have a corkscrew.

                                                                                                                                            rub a walnut on damaged wooden furniture

                                                                                                                                              kids fall out of bed

                                                                                                                                                use toothpaste to clear up hazy car

                                                                                                                                                  58

                                                                                                                                                    59 keep pizza out while driving home

                                                                                                                                                      60 put your straw through the tab to keep it from rising

                                                                                                                                                        hold oreos with a fork so your fingers

                                                                                                                                                          Never lose your remotes again

                                                                                                                                                            hiding your emergency money

                                                                                                                                                              use a bread tab to hold your spot on a roll

                                                                                                                                                                if you are at a hotel and run out of chargers

                                                                                                                                                                  keep a square of cardboard in a ziplock bag

                                                                                                                                                                    If you need to pee or smoke at a bar

                                                                                                                                                                      drill holes in the bottom of your garbage

                                                                                                                                                                        use an accented letter as your passcode

                                                                                                                                                                          use a squeeze ketchup bottle top with your shopvac

                                                                                                                                                                            do something unusual when locking the door

                                                                                                                                                                              when heating leftovers space out a circle in the middle

                                                                                                                                                                                dont burn yourself in those hard to reach candles

                                                                                                                                                                                  put a small amount of water in a glass when you microwave your pizza

                                                                                                                                                                                    75 use a piece of paper to organize

                                                                                                                                                                                      use half a pool noodle

                                                                                                                                                                                        pencil case to store cables

                                                                                                                                                                                          78 clothespin to hold nail

                                                                                                                                                                                            79 make blts

                                                                                                                                                                                              80 take a picture of your fridge

                                                                                                                                                                                                81 fill plastic water bottles

                                                                                                                                                                                                  82 right ways to eat chips

                                                                                                                                                                                                    99 if your plug keeps failing

                                                                                                                                                                                                      100 put the banana on the wire

                                                                                                                                                                                                        88 before you throw away a post it

                                                                                                                                                                                                          Source: Reddit LifeProTips

                                                                                                                                                                                                          There you go, 100 awesome life hacks that you can try right now to make your life a lot easier!

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