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An Eye Drop Has Been Developed To Dissolve Cataracts

An Eye Drop Has Been Developed To Dissolve Cataracts

A new study conducted by researchers in the US has found that a new drug that can be delivered directly into the eye via an eye dropper can shrink down and, in some cases, even dissolve cataracts. Cataracts are the leading cause of blindness affecting tens of millions of people. To date the only way to treat them is painful and often expensive surgery. The eye drops have yet to be tested on humans, but this is to be the next stage of the study.

Jonathan King, a molecular biologist at Massachusetts Institute of Technology in Cambridge not affiliated with the study said that “This is a really comprehensive and compelling paper—the strongest I’ve seen of its kind in a decade”. King has been investigating cataract proteins since 2000.

What are cataracts?

The major component of the fiber cells that form the eyes’ lenses are crystallins. Unfortunately, the unique properties of these cells mean that they are prone and susceptible to damage, explains Jason Gestwicki associate professor of pharmaceutical chemistry at UCSF.

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“Shortly after you’re born, all the fiber cells in the eye lose the ability to make new proteins, or to discard old proteins,” said  Gestwicki, “So the crystallins you have in your eye as an adult are the same as those you’re born with.”

These crystallins must maintain the flexibility and transparency of fiber cells if our lenses are to function properly. Proteins known as chaperones keep the crystallins soluble.

Keeping the crystallins healthy is tricky as clumped-together pathological configurations of crystallins are more stable than healthy forms of crystallins. Thus the fiber-cell chaperones need to resist the tendency of crystallins to clump. The clumped-together proteins are called amyloids. These amyloids make it harder for light to pass through the lens creating the cloudiness cataract is known for.

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Scientists do not know exactly what causes cataracts but the majority of cases are age related. The US National Eye Institute reports more than half of all American have a cataract or have had cataract surgery by the age of 80. https://nei.nih.gov/health/cataract/cataract_facts

Cataracts and blindness; a global problem.

A  study that conducted surveys in 39 countries found that globally the number of people who are visually impaired is estimated to be 285 million. Of this figure 39 million are blind (with uncertainties of 10-20%). 33% of the cases of visual impairment were caused by cataracts, while cataracts were the first cause of blindness; making up 51% of all blindness cases. The study indicates that visual impairment, in particular cataracts, is a major health concern.

Most of the people who suffer from blindness live in developing countries. Over half of these people are blind as a result of cataracts. Given that the money and facilities needed to perform a surgical procedure to remove a cataract is not available in many developing countries, having an eye drop as an alternative to surgery could make a tremendous difference.

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The story that sparked the research.

The new eye drops are based on a naturally-occurring steroid called lanosterol. Researches decided to explore the possibility of using lanosterol as a treatment for cataracts after hearing of two children in China who had inherited a congenital form of cataract. The children’s parents had not suffered from cataracts. The children both had a mutation that prevented the production of lanosterol. The parents did not have this mutation.

As the children did not produce lanosterol and got cataracts and the parents were producing lanasterol and did not get cataracts it was thought, by scientists, that the lanosterol could stop the defective crystalline proteins from clumping together and forming cataracts (in the non-congenital cases).

The research.

Lanosterol-based eye drops were used in three types of experiments. Firstly, the scientists worked with human lens in the Laboratory. Secondly they tested the effects on rabbits and finally they tested the eye drops on dogs with naturally occurring cataracts. The results were as following. In the experiment with human lens there was a decrease in cataract size. After six days all but two of the 13 rabbits had experienced a decrees in the severity of their cataracts. Likewise, the cataracts of the dog shrunk almost disappearing. The results were published in Nature.

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The next step.

The study identifies lanosterol as a key molecule in the prevention of amyloids and points to a new way to approach cataract prevention and treatment. The next step is for the researchers to further investigate how the lanostero-based eye drops are working and then to see if they get the same positive results when the drops are tested on humans.

Featured photo credit: Doing Mercy via doingmercy.com

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Last Updated on May 22, 2019

10 Simple Morning Exercises That Will Make You Feel Great All Day

10 Simple Morning Exercises That Will Make You Feel Great All Day

There are lots of studies that show if you do some exercise in the morning, you will be in a better mood all day long. You will have more energy and you will certainly be a better colleague, friend or partner.

One psychologist at Duke University has researched the effects of exercise on depressed patients and he has come to the conclusion that exercise has a definite role in treating this condition and has an important role in preventing people from relapsing.[1] According to the New York Times, scientists have now established that exercise also boosts your brain power.[2]

In addition, there are studies from the Appalachian State University which show that blood pressure can be reduced by doing regular morning exercise.[3]

Here are 10 simple morning exercises that will help you feel great the whole day long. You can include some of them in your morning exercise routine or do them all at home without having to enrol in a gym. Consult your doctor before starting any form of exercise routine if you are new to this.

1. Cat Camel Stretch

Stretching exercises are useful for muscle toning and also preventing arthritis. They can either be dynamic or static.

Dynamic ones such as the cat camel stretch, are particularly useful for doing other exercises in the morning. They are also beneficial at other times of the day, especially after long periods of sedentary work. This one is great for spinal flexibility and is a good warm up exercise.

Kneel down on all fours. Start by rounding your back just like a camel so that your head will try to meet your pelvis. This is the camel position. Then lower and lift your head so that your lower back is arched. This is the cat position. Do these movements slowly and smoothly. About 4 or 5 times.

Here’s a video to guide you through:

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2. Go for a Walk or a Run

This is better done outside so that you can connect with nature but running inside on a treadmill is almost as good. You can time yourself and increase length and time according to your fitness program.

Always have new goals to reach. Start with brisk walking and work up to running. At my age, I am still walking!

The health benefits are considerable. You can build stronger bones and you can help to maintain your weight.

Also, you are helping your heart to stay healthy and keeping your blood pressure low.

Learn more about the benefits of running here: 8 Benefits of Running 5 Minutes Every Day You Didn’t Know

3. Jumping Jacks

Michelle Obama is a great fan of this exercise and has become “Jumper in Chief.”[4] They are great for cardiovascular health and also for toning muscles especially the calves and the deltoids.

Stand with feet together. Jump while spreading your arms and legs. Return to first position and keep going! You can start with doing these for 1 minute and then gradually build up to the number you are comfortable with. Here’s how:

4. Abductor Side Lifts

Watch the video below to see how to do this exercise. These muscles are important because you use them everyday to run, get into the car or onto and off a bicycle. They are very important also for your core stability and prevent the pelvis from tilting.[5]

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Do about 10 to 15 raises for each side like this:

5. Balancing Table Pose

This is a classic yoga pose. It benefits the spine, balance, memory and concentration.

Start with the table pose (hands and knees). Breathe in before starting each movement. As you exhale, raise your left leg parallel to the floor as you raise the right arm, also parallel to the floor. Breathe in as you lower arm and leg. Repeat for the other side. 10 repetitions on each side is a good starting point.

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    6. Leg Squats

    Not just legs are involved but also hips and knees.

    Stand with your feet a bit further out from your hips. Arms are out in front of you. Then lower yourself as if you wanted to sit down until you reach a 90 degree angle. You can go down further if you want to. Then return to the starting position. Repeat 15 times for 2 sets for beginners.

    The benefits are that these exercises help with knee stability and can benefit the leg muscles such as quadriceps, hamstrings and calves.[6]

    7. Push Ups

    You start lying down (face down) but with your body held up at arm’s length. Your hands should be in line with your shoulders. Breathe in as you lower your body. That is fairly easy. Now, as you exhale, you have to get back up to the starting position.

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    An easier version to start with is to bend your legs at the knees so you do not have to lift your whole body.

    Beginners may take up to a month to be able to do 100 push ups so you will have to start with a very small number and gradually increase it.

    This exercise is great for strengthening the chest, shoulders and the triceps. It is a great strengthening exercise for many muscle groups. In fact, most muscles from the toes to the shoulders are being used.

    8. Bicycle Crunches

    There are numerous crunch exercises targeting the abs. The bicycle crunch is a variation where you work more muscle groups. Aim for 15 to 20 reps to start off with.

    Watch the video to see how this is done correctly:

    9. Lunges

    Stand with feet shoulder width apart. Place your hand on your hips. Take one giant step forward with the right leg. Make sure the knee does not go too far forward, that is, past your toes. The left knee will go down to almost floor level. Alternate the legs as you go on.

    Try to do a set of between 8 and 12 reps for each leg. It is important to allow for a day of rest, so this exercise should be done on alternate days, especially if you are using weights.

    This exercise is great for strengthening and toning the quadriceps, glutes and hamstrings.

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    10. Bicep Curls

    You can do this sitting down so if you spend a lot of time on the phone, this is a great exercise to do.

    Choose suitable dumbbells or another household object that you can easily hold. Sit down with the dumbbell in your hand. You need to sit forward a bit so that your triceps can lean on your thigh to give you support.

    Then bring the weighted arm up to shoulder length and then down again. Exhale as you lift the weight and inhale as you lower it.

    Here’re some important notes before you start doing this exercise:

    Try to do one or two sets of about ten repetitions for each arm and then switch arms.

    These exercises are really useful for toning the arm muscles.[7] In addition, they can strengthen and tone the brachioradialis muscle located in the forearm. These are the muscles we use to pick up things when we flex the arm at the elbow so we use these muscles countless times a day.

    You may have to build in a rest day for the heavier exercises, numbers 6–10. On the rest days, you can do gentler stretching exercises and also some walking or running.

    Morning exercise is not only a great mood booster, but will help you keep your weight down and also sleep better![8] Start including one or some of these exercises in your morning routine!

    More Articles About Exercises for Beginners

    Featured photo credit: Unsplash via unsplash.com

    Reference

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