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An Eye Drop Has Been Developed To Dissolve Cataracts

An Eye Drop Has Been Developed To Dissolve Cataracts
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A new study conducted by researchers in the US has found that a new drug that can be delivered directly into the eye via an eye dropper can shrink down and, in some cases, even dissolve cataracts. Cataracts are the leading cause of blindness affecting tens of millions of people. To date the only way to treat them is painful and often expensive surgery. The eye drops have yet to be tested on humans, but this is to be the next stage of the study.

Jonathan King, a molecular biologist at Massachusetts Institute of Technology in Cambridge not affiliated with the study said that “This is a really comprehensive and compelling paper—the strongest I’ve seen of its kind in a decade”. King has been investigating cataract proteins since 2000.

What are cataracts?

The major component of the fiber cells that form the eyes’ lenses are crystallins. Unfortunately, the unique properties of these cells mean that they are prone and susceptible to damage, explains Jason Gestwicki associate professor of pharmaceutical chemistry at UCSF.

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“Shortly after you’re born, all the fiber cells in the eye lose the ability to make new proteins, or to discard old proteins,” said  Gestwicki, “So the crystallins you have in your eye as an adult are the same as those you’re born with.”

These crystallins must maintain the flexibility and transparency of fiber cells if our lenses are to function properly. Proteins known as chaperones keep the crystallins soluble.

Keeping the crystallins healthy is tricky as clumped-together pathological configurations of crystallins are more stable than healthy forms of crystallins. Thus the fiber-cell chaperones need to resist the tendency of crystallins to clump. The clumped-together proteins are called amyloids. These amyloids make it harder for light to pass through the lens creating the cloudiness cataract is known for.

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Scientists do not know exactly what causes cataracts but the majority of cases are age related. The US National Eye Institute reports more than half of all American have a cataract or have had cataract surgery by the age of 80. https://nei.nih.gov/health/cataract/cataract_facts

Cataracts and blindness; a global problem.

A  study that conducted surveys in 39 countries found that globally the number of people who are visually impaired is estimated to be 285 million. Of this figure 39 million are blind (with uncertainties of 10-20%). 33% of the cases of visual impairment were caused by cataracts, while cataracts were the first cause of blindness; making up 51% of all blindness cases. The study indicates that visual impairment, in particular cataracts, is a major health concern.

Most of the people who suffer from blindness live in developing countries. Over half of these people are blind as a result of cataracts. Given that the money and facilities needed to perform a surgical procedure to remove a cataract is not available in many developing countries, having an eye drop as an alternative to surgery could make a tremendous difference.

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The story that sparked the research.

The new eye drops are based on a naturally-occurring steroid called lanosterol. Researches decided to explore the possibility of using lanosterol as a treatment for cataracts after hearing of two children in China who had inherited a congenital form of cataract. The children’s parents had not suffered from cataracts. The children both had a mutation that prevented the production of lanosterol. The parents did not have this mutation.

As the children did not produce lanosterol and got cataracts and the parents were producing lanasterol and did not get cataracts it was thought, by scientists, that the lanosterol could stop the defective crystalline proteins from clumping together and forming cataracts (in the non-congenital cases).

The research.

Lanosterol-based eye drops were used in three types of experiments. Firstly, the scientists worked with human lens in the Laboratory. Secondly they tested the effects on rabbits and finally they tested the eye drops on dogs with naturally occurring cataracts. The results were as following. In the experiment with human lens there was a decrease in cataract size. After six days all but two of the 13 rabbits had experienced a decrees in the severity of their cataracts. Likewise, the cataracts of the dog shrunk almost disappearing. The results were published in Nature.

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The next step.

The study identifies lanosterol as a key molecule in the prevention of amyloids and points to a new way to approach cataract prevention and treatment. The next step is for the researchers to further investigate how the lanostero-based eye drops are working and then to see if they get the same positive results when the drops are tested on humans.

Featured photo credit: Doing Mercy via doingmercy.com

More by this author

Rebecca Beris

Rebecca is a wellness and lifestyle writer at Lifehack.

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Last Updated on July 12, 2021

100 Incredible Life Hacks That Make Life So Much Easier

100 Incredible Life Hacks That Make Life So Much Easier
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Want to learn some quick and easy life hacks that are easy to do, low cost and saves you time?

By tweaking little things in your daily life, it can make your life much more convenient!

Here’re 100 of the most practical life hacks so you can just pick up any of them right away!

83 tie a small piece of bright colored fabric

    84 write random letter

      85 use a rubberband

        86 dorm smell bad

          87 lean your phone on your sunglassess

            89 how to waterproof your shoes

              90 take a picture of the name card

                91 iron inside out

                  92 old newspaper

                    93 tumble try shoes

                      keep a card like this

                        SONY DSC

                          94 soap bar

                            95 make a hole

                              96 drop the battery

                                97 use a coozie

                                  98 when taking a picture

                                    use a clean dust pan

                                      try a pants hanger

                                        use your cellphone light

                                          use a spring from an old pen

                                            quick and easy iphone speaker

                                              user binder clips

                                                wrap a wet paper towel around your beverage

                                                  put pancake mix in a ketchup bottle

                                                    clean out an old lotion bottle for your beach

                                                      use a muffin tin to serve condiments at a bbq

                                                        doritos are great for kindling

                                                          use nail polish to identify different keys

                                                            use a hanging shoe rack to store cleaning supplies

                                                              freeze grapes to chill white wine without

                                                                use paper clips to organize your cables

                                                                  almost finished your jar of nutella

                                                                    sick of having a box full of tangled

                                                                      unroll the rim to increase the capacity

                                                                        cut open toilet paper rolls and use as a cuff

                                                                          remove the stem from strawberries

                                                                            turn an old bottle into a simple little cord holder

                                                                              for iced coffee and iced cappuccino, use frozen coffee cubes

                                                                                how to fold a fitted bed sheet

                                                                                  tired of snoozing past your alarm

                                                                                    place a rubber band around an open paint can to wipe your brush on

                                                                                      ut a wooden spoon across a boiling pot

                                                                                        use bread clips to save flip-flops

                                                                                          take pictures of friends holding items

                                                                                            how i always know which headphone is the left one

                                                                                              put a stocking over the end of a vacuum

                                                                                                How to make sure you drink enough water

                                                                                                  user a can opener to open blister

                                                                                                    good sandwich guide

                                                                                                      turn your muffin pans upside down

                                                                                                        50 pounds of groceries and living on the 5th floor

                                                                                                          the right way to make a blt

                                                                                                            add one teaspoon of baking soda

                                                                                                              38

                                                                                                                hair straighteners equals to collar irons

                                                                                                                  stack your clothes vertically to see them all

                                                                                                                    the right way to make cookies in the summer

                                                                                                                      how to clean a blender

                                                                                                                        the right way to eat a popsicle

                                                                                                                          use bread clips to label and organize power cords

                                                                                                                            to get the built up residue off of your shower head

                                                                                                                              user a hair clip to orgainize long wires

                                                                                                                                a frozen saturated sponge in a bag

                                                                                                                                  rub stuck zipper teeth with a graphite pencil

                                                                                                                                    use a soda pop tab

                                                                                                                                      50

                                                                                                                                        51 How to multiply large numbers in your head.

                                                                                                                                          52 How to open a bottle if you dont have a corkscrew.

                                                                                                                                            rub a walnut on damaged wooden furniture

                                                                                                                                              kids fall out of bed

                                                                                                                                                use toothpaste to clear up hazy car

                                                                                                                                                  58

                                                                                                                                                    59 keep pizza out while driving home

                                                                                                                                                      60 put your straw through the tab to keep it from rising

                                                                                                                                                        hold oreos with a fork so your fingers

                                                                                                                                                          Never lose your remotes again

                                                                                                                                                            hiding your emergency money

                                                                                                                                                              use a bread tab to hold your spot on a roll

                                                                                                                                                                if you are at a hotel and run out of chargers

                                                                                                                                                                  keep a square of cardboard in a ziplock bag

                                                                                                                                                                    If you need to pee or smoke at a bar

                                                                                                                                                                      drill holes in the bottom of your garbage

                                                                                                                                                                        use an accented letter as your passcode

                                                                                                                                                                          use a squeeze ketchup bottle top with your shopvac

                                                                                                                                                                            do something unusual when locking the door

                                                                                                                                                                              when heating leftovers space out a circle in the middle

                                                                                                                                                                                dont burn yourself in those hard to reach candles

                                                                                                                                                                                  put a small amount of water in a glass when you microwave your pizza

                                                                                                                                                                                    75 use a piece of paper to organize

                                                                                                                                                                                      use half a pool noodle

                                                                                                                                                                                        pencil case to store cables

                                                                                                                                                                                          78 clothespin to hold nail

                                                                                                                                                                                            79 make blts

                                                                                                                                                                                              80 take a picture of your fridge

                                                                                                                                                                                                81 fill plastic water bottles

                                                                                                                                                                                                  82 right ways to eat chips

                                                                                                                                                                                                    99 if your plug keeps failing

                                                                                                                                                                                                      100 put the banana on the wire

                                                                                                                                                                                                        88 before you throw away a post it

                                                                                                                                                                                                          Source: Reddit LifeProTips

                                                                                                                                                                                                          There you go, 100 awesome life hacks that you can try right now to make your life a lot easier!

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