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Do Antidepressants Work For You? Brain Waves May Predict

Do Antidepressants Work For You? Brain Waves May Predict

For almost half a century, patients suffering from severe depressive and anxiety disorders have relied on antidepressants for relief. But to any depression sufferer, finding the right medication is the hardest part of drug therapy. Not every drug works the same and figuring out what prescription interacts correctly with the body can take months to years.

The study

Luckily, we’re in 2016, a year in which psychopharmacology has advanced dramatically – and this notion echoes with antidepressants. A new study published in the Semel Institute for Neuroscience and Human Behavior at UCLA aimed to predict whether or not an antidepressant would work in the long term.

According to Dr. Andrew Leuchter, the lead author of the study, researchers were able to predict the outcome of the selective serotonin reuptake inhibitor (SSRI) antidepressant drug Lexapro, using brain wave recordings. Additionally, researchers were able to analyze electroencephalogram recordings to foresee if recovery or relapse from depressive episodes were to occur.

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“Knowing whether a medication is going to work could eliminate weeks of waiting for the patient, and get them on effective treatment more quickly,” Dr. Leuchter said.

Lexapro, like other antidepressants, works by increasing the neurotransmitter serotonin, which is responsible for mood, energy, and behavior. However, serotonin is also able to stabilize slow and fast brain waves caused by a chemical reaction.

In the study, researchers gathered data from 194 clinically depressed patients, aged 18 to 70 years old. Participants were broken down into three groups: two comprised of 70 and 76 patients, each treated with Lexapro for seven weeks, and the third group of 48 patients treated with a placebo.

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“The researchers tested whether brain wave recordings in the first week of treatment would show that the antidepressant (as compared with a placebo) corrected the frequency imbalance – and predict a beneficial effect of medication on an individual’s depression after seven weeks of treatment,” UCLA researchers stated.

Before taking any drugs, all patients received an electroencephalogram and a second one after they completed one full week of treatment or placebo. It was immediately obvious that after only one week of therapy with Lexapro, brain wave recordings began having a distinct pattern compared to patients who took a placebo.

The findings

After reviewing numerous brain wave recordings, Dr. Leuchter became convinced that something important was discovered.

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“Our biomarker selectively predicted remission with medication, but not placebo. This confirmed that we can differentiate a true, specific response to a drug from a non-specific placebo response. To our knowledge, this is the first time that a biomarker that differentiates placebo remission from drug remission has been reported,” researchers concluded.

Although researchers struck gold by testing Lexapro, more antidepressant drugs are expected to receive new clinical trials, but this time, utilizing brain wave recordings. Researchers hope to improve wait time and save money for patients receiving drug therapy. The testing continues.

10 Fast Facts About Antidepressants

Before taking antidepressants, there are important facts you should know. According to clinical psychologists, if patients would’ve been notified about these deadly risks, the death toll associated with antidepressants would be significantly lower.

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1. Do NOT take antidepressants if you’ve taken MAOIs (another class of antidepressants). You MUST wait at least 14 days.
2. Antidepressants may increase the risk of suicidal thoughts.
3. Some antidepressant drugs may cause significant weight gain.
4. The full therapeutic benefit of antidepressants can take up to 6 weeks.
5. Do NOT abruptly discontinue antidepressants without advising your doctor.
6. NEVER mix antidepressant drugs with the opioid painkiller Tramadol.
7. Although few antidepressants can treat sexual disorders, others can cause sexual dysfunction.
8. If you have a sudden high fever and see hallucinations, get medical attention right away – you may have Serotonin Syndrome.
9. You should NEVER mix your antidepressant medication with other antidepressants.
10. If one drug does not work for you, don’t stress, there are plenty others to try.

Featured photo credit: Lea Suzuki via sfgate.com

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Jose Florez

Mental Health Writer

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Published on October 5, 2020

What Are Creative Problem Solving Skills (And How To Improve Yours)

What Are Creative Problem Solving Skills (And How To Improve Yours)

I think we’re all familiar with that feeling of needing to solve a problem, trying way too hard, getting frustrated, and then throwing our hands up in defeat. For example, when my editor assigned me this topic, the structure and concept of the piece weren’t instantly clear to me. I had to problem-solve to figure out how to even begin. But problem-solving isn’t quite so linear. It’s not just a matter of brute force. You can’t just muscle your way through. This is where creative problem solving comes in.

Creative problem solving is about using what we know about how the brain works to come up with outside-the-box solutions to creative problems. Sure, we can do things the same way we’ve always done them. Or we can try creative problem solving, which means we spend time ideating (a.k.a. brainstorming), collaborating, ruminating, and refining to land on better and more novel solutions than we could have if we tried to force or rush a solution.

Stages of Creative Problem Solving

There’s no right or wrong way to try creative problem solving, but there are some stages that can help you integrate it into your creative process. Here are the 4 stages of creative problem solving

1. Ideating/Brainstorming

If we’re using creative problem solving, we’re not just going with the first idea that pops into our heads. Brainstorming is crucial to come up with more novel solutions.

One of the most important things to keep in mind during brainstorming is that this is not the time to evaluate or judge ideas. The goal of ideating is to come up with as many ideas as possible.

There’s an improvisation rule called “Yes, And” or the rule of agreement that can help you get the most out of your brainstorming sessions.[1] The idea is simple. If you’re brainstorming in a group and someone tells you an idea, you need to go along with that idea. That’s the “Yes” part of “Yes, And.” Then, you can take it a step further by trying to add to that person’s idea.

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Let’s say you and your team are trying to figure out how to rebrand your shoe company. Your colleague says you could use a mascot. If you’re using improv’s “Yes, And” rule, you might agree and say that the mascot could be a shoe or a sock or a lonely sock looking for a shoe.

During the ideation stage, no one should be worried about which ideas are good and which are bad. Everyone is trying to come up with as many ideas as possible, and everyone should be trying to make the most of everyone else’s ideas.

“Yes, And” can also work if you’re creative problem solving alone. Instead of discarding ideas, you should be saying yes to your ideas, writing them all down, and trying to make all of them as workable as possible. But before you get too far in your creative process, it’s important to run your ideas by someone else.

2. Collaboration

I know sometimes you don’t want to share your ideas with other people. Maybe you’re self-conscious or you just don’t think that your idea is ready for prime time. However, it’s important to step out of your comfort zone and let other people join your creative process if you want to reach the best possible creative solution.

When we’re working in a team, it’s important to not judge each other’s ideas until we’re safely in the final stage of the creative problem-solving process. That means no critiques, no evaluations, and no snarky comments. Not yet, at least.

The reason to hold off on evaluating ideas at this stage is that some people tend to shut down if their ideas are judged too early. There’s a concept called creative suppression that occurs when people stop a creative pursuit temporarily due to feeling judged, shamed, or embarrassed.[2] Even worse, creative mortification is when judgment, shame, or embarrassment makes you quit your creative pursuit altogether.

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When you’re collaborating with others while creative problem solving, you don’t want to shut anyone down. The more people who are actively engaged in the creative process the better.

In improv, there’s something called “group mind.” The basic idea is that a group can come up with a better solution than any single individual. It makes sense since each person in the group enters the creative process with their own strengths, knowledge, background, experience, and ideas. That means that when the group is working harmoniously, the best contributions of each individual will be reflected in the team’s solution, making that solution far better than what any individual could have come up on their own.

So, find someone you trust and lay the ground rules for your collaboration. Tell each other that you won’t be judging each other’s work just yet to bring out the best and make it as creative and effective as possible.

3. Pause

It can seem counterintuitive to pause during the creative process. But to tap into the creative unconscious parts of your brain, you need to stop forcing it and let your mind wander.

The part of your brain that you’re using to understand this article right now is not necessarily the part that’s going to come up with the most novel solution to your problem. To start using your creative unconscious brain, you need to take a break.

Have you ever had that experience of struggling with a problem and then effortlessly figuring it out while you were showering or walking the dog? That’s your unconscious brain doing the heavy lifting.

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This part of the brain can’t be forced into creative problem solving, so stop consciously obsessing about your problem for a while. Take a walk. Go for a drive. Let your mind wander. Dream. This gives your unconscious mind a chance to sort information and come up with some truly novel solutions.

The bonus to letting your unconscious take over is that it’s effortless. Conscious thought requires you to burn lots of energy, while unconscious doesn’t. So, stop trying so hard and let ideas come to you.

4. Refine

At some point, you’re going to have to start evaluating, eliminating, and refining your ideas to get to the best solution. But if you’ve brainstormed, collaborated, and ruminated enough, you should have plenty of material to work with.

An Example of Creative Problem Solving

I think it’s helpful to walk through an example of creative problem-solving in action. Let’s go back to the example of me writing this article.

First, I was presented with the problem, so I started brainstorming and “Yes, And”-ing myself. I thought about everything I already know about creative problem solving and did some preliminary research, but I still didn’t have a structure or theme to tie my ideas together.

Once the problem was marinating in my mind, I started talking to people. I talked to an old friend about my initial ideas about the article, but I still didn’t have any words on the page just yet.

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Then, one morning, the article seemed to come fully formed while I was showering. I could see which examples would work best and how to structure the article. So, I sat down to write and refine the ideas. During the refining stage, I swung back to the collaboration stage when my editor further refined and improved my ideas.

It’s important to remember that these four stages of creative problem solving aren’t linear. They’re circular. After I refine an idea, I can go back to brainstorming, collaborating, and pausing as needed to develop and improve that idea.

Bottom Line

Creative problem solving is, first and foremost, creative. You have to give yourself time and space to be able to reflect and ruminate. It’s also important to collaborate as necessary to improve your ideas with the help of other people.

The most important thing to keep in mind is that you can’t force creative problem-solving. Forcing it only leads to frustration and failure, so give yourself some time and a team you trust to come up with the best possible solution to your problem.

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Featured photo credit: Per Lööv via unsplash.com

Reference

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