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Do Antidepressants Work For You? Brain Waves May Predict

Do Antidepressants Work For You? Brain Waves May Predict

For almost half a century, patients suffering from severe depressive and anxiety disorders have relied on antidepressants for relief. But to any depression sufferer, finding the right medication is the hardest part of drug therapy. Not every drug works the same and figuring out what prescription interacts correctly with the body can take months to years.

The study

Luckily, we’re in 2016, a year in which psychopharmacology has advanced dramatically – and this notion echoes with antidepressants. A new study published in the Semel Institute for Neuroscience and Human Behavior at UCLA aimed to predict whether or not an antidepressant would work in the long term.

According to Dr. Andrew Leuchter, the lead author of the study, researchers were able to predict the outcome of the selective serotonin reuptake inhibitor (SSRI) antidepressant drug Lexapro, using brain wave recordings. Additionally, researchers were able to analyze electroencephalogram recordings to foresee if recovery or relapse from depressive episodes were to occur.

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“Knowing whether a medication is going to work could eliminate weeks of waiting for the patient, and get them on effective treatment more quickly,” Dr. Leuchter said.

Lexapro, like other antidepressants, works by increasing the neurotransmitter serotonin, which is responsible for mood, energy, and behavior. However, serotonin is also able to stabilize slow and fast brain waves caused by a chemical reaction.

In the study, researchers gathered data from 194 clinically depressed patients, aged 18 to 70 years old. Participants were broken down into three groups: two comprised of 70 and 76 patients, each treated with Lexapro for seven weeks, and the third group of 48 patients treated with a placebo.

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“The researchers tested whether brain wave recordings in the first week of treatment would show that the antidepressant (as compared with a placebo) corrected the frequency imbalance – and predict a beneficial effect of medication on an individual’s depression after seven weeks of treatment,” UCLA researchers stated.

Before taking any drugs, all patients received an electroencephalogram and a second one after they completed one full week of treatment or placebo. It was immediately obvious that after only one week of therapy with Lexapro, brain wave recordings began having a distinct pattern compared to patients who took a placebo.

The findings

After reviewing numerous brain wave recordings, Dr. Leuchter became convinced that something important was discovered.

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“Our biomarker selectively predicted remission with medication, but not placebo. This confirmed that we can differentiate a true, specific response to a drug from a non-specific placebo response. To our knowledge, this is the first time that a biomarker that differentiates placebo remission from drug remission has been reported,” researchers concluded.

Although researchers struck gold by testing Lexapro, more antidepressant drugs are expected to receive new clinical trials, but this time, utilizing brain wave recordings. Researchers hope to improve wait time and save money for patients receiving drug therapy. The testing continues.

10 Fast Facts About Antidepressants

Before taking antidepressants, there are important facts you should know. According to clinical psychologists, if patients would’ve been notified about these deadly risks, the death toll associated with antidepressants would be significantly lower.

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1. Do NOT take antidepressants if you’ve taken MAOIs (another class of antidepressants). You MUST wait at least 14 days.
2. Antidepressants may increase the risk of suicidal thoughts.
3. Some antidepressant drugs may cause significant weight gain.
4. The full therapeutic benefit of antidepressants can take up to 6 weeks.
5. Do NOT abruptly discontinue antidepressants without advising your doctor.
6. NEVER mix antidepressant drugs with the opioid painkiller Tramadol.
7. Although few antidepressants can treat sexual disorders, others can cause sexual dysfunction.
8. If you have a sudden high fever and see hallucinations, get medical attention right away – you may have Serotonin Syndrome.
9. You should NEVER mix your antidepressant medication with other antidepressants.
10. If one drug does not work for you, don’t stress, there are plenty others to try.

Featured photo credit: Lea Suzuki via sfgate.com

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Jose Florez

Mental Health Writer

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Published on November 18, 2019

How to Think Critically: 5 Powerful Techniques

How to Think Critically: 5 Powerful Techniques

Critical thinking is the art of filtering through information to reach an unbiased, logical decision that guides better thought and action. It can be learned through powerful techniques listed in this article.

Before you read further, it is important for you to know that critical thinking is a state of mind, not a tool or strategy.

If you are bogged down in the trivial day to day matters of your professional and personal life, learning skills to develop your ability to think critically can help you rise above these issues and focus your energies where they are needed – to solve problems and accomplish objectives.

It stands to reason that the better the learning techniques, the better critical thinking and reasoning will be. My experience in helping people grow means I know exactly what is needed to teach critical thinking (hint: it’s not just pondering over the problem).

There are 5 powerful techniques that form the base of critical thinking:

  1. Analytical thinking
  2. Communication
  3. Creativity
  4. Open-mindedness
  5. Problem-solving

Once you learn the techniques listed and start employing them in your daily life, you’ll quickly start to notice a change in the way you approach problems and consequently, how you resolve them too.

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1. Analytical Thinking

Analytical thinking is the gathering and breaking down of information into small bites that help make sense of it.

To use it for critical thinking:

  • Be very clear on why you need the information. This is to recognize your limitations and employ foresight to overcome them.
  • Gather information from as many sources as you can: peers and experts, podcasts, relevant literature and any other place you can think of.
  • Rephrase questions multiple times to get different perspectives on data available and possibly arrive at different solutions.
  • Break down the data into factual subsets and relate each to the issue at hand.
  • Think on paper to make new connections. Write, doodle, make mind-maps or use spreadsheets. Data presented visually can help you make new connections make sense of emerging patterns.
  • Tidy up the workplace. Once data has been gathered, your workspace and your brain will both be cluttered with excess information. Neaten the physical space and clear your mind with meditation. The change in focus will help you view the information in a new light, potentially helping you reach newer, better conclusions.

Want more information and tips on adopting this powerful technique? What Are Analytical Skills and How to Strengthen Them For Success has all the information you need.

2. Communication

Communication is a key technique for critical thinking as it gives you access to the thoughts of people around you.

Data can be communicated through audio and visual means and in many cases, through careful observation of body language:

  • Ask for different points of view and seek justification for the same thing. When you invest in the matter, you will be able to explore all options to reach the best solution.
  • Listening without interrupting and only asking questions or voicing concerns once the speaker is done helps you make better connections.
  • Be 100% focused on a verbal or written discussion, you can better hear/read the opinions of the people involved.
  • Paraphrase the speaker/writer’s point of view and ask for affirmation. This enables you to pay full attention and use the input to think critically.
  • In a meeting, subtle communication cues are given by the body language of fellow attendees. An imperceptible frown, a small nod, pencil tapping etc. will all give you clues to what they are really thinking, just in case their actions are not in sync with their words!
  • Active observation, where you are watching and listening intently helps you know what to make of the information that is being passed around. It gives you clues to the general opinion about the topic under discussion and opens up new possibilities.

The information you gather through such communication will be invaluable in thinking critically to arrive at a decision that is holistic and unbiased.

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3. Creativity

Critical thinking is an art, and like any art form, its lifeblood is creativity. To really learn critical thinking, you need to include elements of creativity in the process!

  • Brainstorm with your team in an all-new location or work-shadow an industry expert to step out of your comfort zone. You could be surprised by the ideas that flow at a picnic or a game of billiards!
  • Gather data and tabulate it in the form of colorful, eye-catching charts, graphs and mind maps. The simple exercise makes your mind bring data together in different ways and presents them so multiple unique conclusions can be reached, giving you the flexibility to choose the best one.
  • Play brain games such as Sudoku or chess to appreciate how different factors can be manipulated to reach a preferred outcome. These games help make connections between previously disconnected nerves, giving your brain the power to find multiple pathways to answering problems.
  • In a similar vein, you can forge new neural connections by learning a new skill, a new language or even a new recipe!

I break down creativity in my other article What is Creativity? We All Have It, and Need It. If you want to be good at critical thinking, you need to adopt creativity!

4. Open-Mindedness

It’s easy to say you’re open minded but is your mind really open?

To get an idea,

  • Be brutally honest about your strengths and weaknesses, and how these will impact the matter at hand.
  • Hear an opinion that conflicts with your own without forming a response before the opinion is fully voiced.
  • Acknowledge that there may be more than one approach to solving a problem and that they may all be right in some way.
  • Consider your true feelings when you will implement any required changes.
  • Disregard your long-held beliefs and assumptions and let go of habits.
  • Imagine the decision-making factors placed on weighing scales. Are they balanced?

Open-mindedness is a powerful technique for critical thinking. New possibilities can be uncovered, helping you resolve personal and professional matters in a manner that doesn’t frustrate you or alienate the other party.

5. Problem-Solving

Critical thinking is heavily dependent on problem-solving. An effective critical thinker will be a problem solver with the foresight to anticipate roadblocks and negative outcomes, and the experience and presence of mind to resolve them quickly and move on.

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One of the most effective problem-solving methodologies is the 5 Whys Analysis. Invented by Sakichi Toyoda, the founder of Toyota Motors in the 1950s, it has been used successfully by the automobile giant to get to the root cause of problems.

The idea behind this is simple: start with the end problem and keep asking why until you get to the root cause of it.

The general idea is that asking why 5 times from the effect is enough to get to the cause, hence the name. However, the methodology does not limit the questions to 5, and why can be asked as many times as need to peel away the layers until a satisfactory answer is reached.

To use the 5 Whys Analysis, start off by listing the problem and writing why in front of it. The next point in the list should be answer to the first why with another why in front of it. Continue answering the question asked above followed by a why until you’ve asked the question 5 times and answered it six times. 99% of the time, the last answer will be the root cause of the problem stated in the first point.

For example, consider the a commonly given scenario where a vehicle does not start.

  1. Vehicle will not start. Why?
  2. Battery is dead. Why?
  3. The alternator is not functioning. Why?
  4. The alternator belt has broken. Why?
  5. It was old and worn out. Why?
  6. The car is not maintained according to manufacturer’s recommendation.

By this example, it is clearly demonstrated that 5 whys were asked to reach the root cause of the problem.

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The 5 techniques discussed here are important for effective critical thinking. When employed regularly they will become a habit and will definitely improve your critical thinking skills so you can get better at predicting and resolving issues that concern you and your environment.

Over the years, the 5 Whys Analysis has been adopted by millions to reach the root cause of their personal and professional problems. Industry giant Six Sigma has also incorporated the 5x Why Analysis in the Analyze phase of their DMAIC methodology.[1]

Final Thoughts

Is critical thinking a new-fangled notion? Not at all. Its history can be traced back to Socrates who questioned commonly held beliefs. This practice was carried forward by leading scholars and thinkers from different times such as Aristotle and Plato, Colet and Moore, Descartes, Galileo and Newton.[2]

Today’s world is dependent on critical thinking to resolve all sorts of issues. It is now indispensable for issues ranging from personal relationships to professional jobs and those involving the global community.

The 5 techniques discussed here are important for effective critical thinking. When employed regularly, they will become a habit and will definitely improve your critical thinking skills so you can get better at predicting and resolving issues that concern you and your environment.

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Featured photo credit: Mariya Pampova via unsplash.com

Reference

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