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Scientists Find Why Elephants Are Less Likely To Get Cancer

Scientists Find Why Elephants Are Less Likely To Get Cancer

Did you know that besides humans, animals also die of cancer at the same percentage as us? It is also believed that some animals are moving toward extinction because of this deadly illness. And then, there are those animals that never get cancer. One big example is elephants.

The reason behind why elephants are less likely to get cancer is due to additional copies of a gene encoding tumor protein suppressor, p53. A new study performed by the researchers at Huntsman Cancer Institute at University of Utah Health Sciences, and researchers from the Ringling Bros. Center for Elephant Conservation, shows this phenomenal result. Also, the study conducted that elephants have built-in powerful system of killing cancerous cells.

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Elephants dying out of cancer is 5% compared to 11 to 25% of humans dying out of cancer have baffled the scientists for many years. In order to solve this mystery, the scientists, along with the Ringling Bros. Center for Elephant Conservation, Primary Children’s Hospital, and Utah’s HogleZoo, have performed experiments for several years. On a conclusion, they have discovered that elephants have 38 additional modified copies of a gene that encodes p53, a compound that subdues tumor development. Comparatively, humans have only 2. To come up with a solid answer, the scientists compared the elephants genes with healthy human genes, and genes from a group of patients suffering from Li-Fraumeni Syndrome. The patients have a 90% chance of developing cancer in their lifetime, and have only 1 copy of p53. The lifespan of elephants are from 50 to 70 years, and they have 100 times more cells than us. This made the scientists wonder that among so many cells, at least one or two would trigger cancer. But they don’t.

These results have been published in the Journal of the American Medical Association (JAMA).

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“Nature has already figured out how to prevent cancer. It’s up to us to learn how different animals tackle the problem so we can adapt those strategies to prevent cancer in people,” said co-senior author Joshua Schiffman, M.D., pediatric oncologist at Huntsman Cancer Institute, University of Utah School of Medicine , and Primary Children’s Hospital.

Schiffman and his team scoured through the African elephant genome, and uncovered 40 copies of genes that code for p53. This is a huge amount, given that humans have only 2 copies. What the team did next was they extracted white blood cells from the elephants during their routine check-ups, and subjected the cells to treatments that damage DNA. As a reply, the cells self-destructed, meaning, the cells died, and would be unable to turn into cancer.

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“If you kill the damage cell, it’s gone, and it can’t turn into cancer. This maybe more effective of an approach to cancer prevention than trying to stop a mutated cell from dividing and not being able to completely repair itself,” said Schiffman.

The team, then did another experiment. In order to see if more p53 can prevent cancer, they took cells from elephants (n=8), healthy humans (n=10), and Li-Fraumeni Syndrome patients (n=10), and exposed the cells to radiation. The response showed that elephant cells self-destructed at twice the rate of healthy humans, and more than five times the rate of Li-Fraumeni patients (14.6%, 7.2% and 2.7% respectively). These results supported the idea that more p53 can prevent against cancer. The scientists believe that too much p53 is nature’s way of protecting these majestic animals from cancer.

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Of course, there will be further studies and researches to see if the same can be applied to humans. “If the elephants can hold the key to unlocking some of the mysteries of cancer, then we will see an increased awareness of the plight of elephants worldwide,” said Eric Peterson, elephant manager at Utah’s Hogle Zoo. “What a fantastic benefit: elephants and humans living longer, better lives.”

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Sumaiya Kabir

Sumaiya is a passionate writer who shares thoughts and ideas to help people improve themselves.

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Last Updated on March 24, 2021

8 Smart Home Gadgets You Need in Your House

8 Smart Home Gadgets You Need in Your House

We’ve all done it. We’ve gone out and bought useless gadgets that we don’t really need, just because they seemed really cool at the time. Then, we are stuck with a bunch of junk, and end up tossing it or trying to sell it on Ebay.

On the other hand, there are some pretty awesome tech inventions that are actually useful. For instance, many of the latest home gadgets do some of your work for you, from adjusting the home thermostat to locking your front door. And, if used as designed, these tools should really help to make your life a lot easier—and that’s not just a claim from some infomercial trying to sell you yet another useless gadget.

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Take a look at some of the most popular “smart gadgets” on the market:

1. Smart Door Locks

A smart lock lets you lock and unlock your doors by using your smartphone, a special key fob, or biometrics. These locks are keyless, and much more difficult for intruders to break into, making your home a lot safer. You can even use a special app to let people into your home if you are not there to greet them.

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2. Smart Kitchen Tools

Wouldn’t you just love to have a pot of coffee waiting for you when you get home from work? What about a “smart pan” that tells you exactly when you need to flip that omelet? From meat thermometers to kitchen scales, you’ll find a variety of “smart” gadgets designed to make culinary geeks salivate.

3. Mini Home Speaker Play:1

If you love big sound, but hate how much space big speakers take up, and if you want a stereo system that is no bigger than your fist, check out the Play:1 mini speaker. All you have to do is plug it in, connect, and then you can stream without worrying about any interruptions or interface. You can even add onto it, and have different music playing in different rooms.

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4. Wi-Fi Security Cameras

These are the latest in home security, and they connect to the Wi-Fi in your home. You can use your mobile devices to monitor what is going on in your home at all times, no matter where you are. Options include motion sensors, two-way audio, and different recording options.

5. Nest Thermostat

This is a thermostat that lives with you. It can sense seasonal changes, temperature changes, etc., and it will adjust itself automatically. You will never have to fiddle with a thermostat dial or keypad again, because this one basically does all of the work for you. It can also help you to save as much as 12% on heating bills, and 15% on cooling bills.

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6. Smart Lighting

Control your home lighting from your remote device. This is great if you are out and want to make sure that there are some lights on. It is designed to be energy efficient, so it will pay for itself over time because you won’t have to spend so much on your monthly energy bills.

7. Google Chromecast Ultra

Whether you love movies, television shows, music, etc., you can stream it all using Google Chromecast Ultra. Stream all of the entertainment you love in up to 4K UHD and HDR, for just $69 monthly.

8. Canary

This home security system will automatically contact emergency services when they are needed. This system offers both video and audio surveillance, so there will be evidence if there are any break-ins on your property. You can also use it to check up on what’s happening at home when you are not there, including to make sure the kids are doing their homework.

Featured photo credit: Karolina via kaboompics.com

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