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Scientists Find Why Elephants Are Less Likely To Get Cancer

Scientists Find Why Elephants Are Less Likely To Get Cancer

Did you know that besides humans, animals also die of cancer at the same percentage as us? It is also believed that some animals are moving toward extinction because of this deadly illness. And then, there are those animals that never get cancer. One big example is elephants.

The reason behind why elephants are less likely to get cancer is due to additional copies of a gene encoding tumor protein suppressor, p53. A new study performed by the researchers at Huntsman Cancer Institute at University of Utah Health Sciences, and researchers from the Ringling Bros. Center for Elephant Conservation, shows this phenomenal result. Also, the study conducted that elephants have built-in powerful system of killing cancerous cells.

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Elephants dying out of cancer is 5% compared to 11 to 25% of humans dying out of cancer have baffled the scientists for many years. In order to solve this mystery, the scientists, along with the Ringling Bros. Center for Elephant Conservation, Primary Children’s Hospital, and Utah’s HogleZoo, have performed experiments for several years. On a conclusion, they have discovered that elephants have 38 additional modified copies of a gene that encodes p53, a compound that subdues tumor development. Comparatively, humans have only 2. To come up with a solid answer, the scientists compared the elephants genes with healthy human genes, and genes from a group of patients suffering from Li-Fraumeni Syndrome. The patients have a 90% chance of developing cancer in their lifetime, and have only 1 copy of p53. The lifespan of elephants are from 50 to 70 years, and they have 100 times more cells than us. This made the scientists wonder that among so many cells, at least one or two would trigger cancer. But they don’t.

These results have been published in the Journal of the American Medical Association (JAMA).

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“Nature has already figured out how to prevent cancer. It’s up to us to learn how different animals tackle the problem so we can adapt those strategies to prevent cancer in people,” said co-senior author Joshua Schiffman, M.D., pediatric oncologist at Huntsman Cancer Institute, University of Utah School of Medicine , and Primary Children’s Hospital.

Schiffman and his team scoured through the African elephant genome, and uncovered 40 copies of genes that code for p53. This is a huge amount, given that humans have only 2 copies. What the team did next was they extracted white blood cells from the elephants during their routine check-ups, and subjected the cells to treatments that damage DNA. As a reply, the cells self-destructed, meaning, the cells died, and would be unable to turn into cancer.

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“If you kill the damage cell, it’s gone, and it can’t turn into cancer. This maybe more effective of an approach to cancer prevention than trying to stop a mutated cell from dividing and not being able to completely repair itself,” said Schiffman.

The team, then did another experiment. In order to see if more p53 can prevent cancer, they took cells from elephants (n=8), healthy humans (n=10), and Li-Fraumeni Syndrome patients (n=10), and exposed the cells to radiation. The response showed that elephant cells self-destructed at twice the rate of healthy humans, and more than five times the rate of Li-Fraumeni patients (14.6%, 7.2% and 2.7% respectively). These results supported the idea that more p53 can prevent against cancer. The scientists believe that too much p53 is nature’s way of protecting these majestic animals from cancer.

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Of course, there will be further studies and researches to see if the same can be applied to humans. “If the elephants can hold the key to unlocking some of the mysteries of cancer, then we will see an increased awareness of the plight of elephants worldwide,” said Eric Peterson, elephant manager at Utah’s Hogle Zoo. “What a fantastic benefit: elephants and humans living longer, better lives.”

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Last Updated on December 9, 2019

5 Simple Ways to Relieve Stress Effectively

5 Simple Ways to Relieve Stress Effectively

Everyone experiences mental stress at one time or another. Maybe you’re starting a new career, job, or business, or you feel incredibly overwhelmed between work, parenting, and your love life (or a lack of it). It could even be that you simply feel that you have way too much to do and not enough time to do it,  plus, on top of everything, nothing seems to be going the way it should!

Yup, we all experience mental stress from time-to-time, and that’s okay as long as you have the tools, techniques and knowledge that allow you to fully relieve it once it comes.

Here are 5 tips for relieving mental stress when it comes so you can function at your best while feeling good (and doing well) in work, love, or life:

1. Get Rationally Optimistic

Mental stress starts with your perception of your experiences. For instance, most people get stressed out when they perceive their reality as “being wrong” in some way. Essentially, they have a set idea of how things “should be” at any given moment, and when reality ends up being different (not even necessarily bad), they get stressed.

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This process is simply a result of perception and can be easily “fixed” by recognizing that although life might not always be going as YOU think it should, it’s still going as it should—for your own benefit.

In fact, once you fully recognize that everything in your life ultimately happens for your own growth, progress, and development—so you can achieve your goals and dreams—your perception works in your favor. You soon process and respond to your experience of life differently, for your advantage. That’s the essence of becoming “rationally optimistic.”

The result: no more mental stress.

2. Unplug

Just like you might need to unplug your computer when it starts acting all crazy, you should also “unplug” your mind.

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How on earth do you unplug your mind? Simple: just meditate.

It isn’t nearly difficult or complicated as some people think, so, if you don’t already meditate, give it a try. Whether you meditate for 5 minutes, 30 minutes, or 2 hours, this is a surefire way to reduce mental stress.

Meditation has been scientifically proven to relax your body (resulting in less mental stress), while also reducing anxiety and high blood pressure.

3. Easy on the Caffeine

Yes, we know, we know—everyone loves a nice java buzz, and that’s okay, but there’s a fine line between a small caffeine pick-me-up and a racing heart and mind that throws you into a frenzy of mental stress.

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Try giving up caffeine for a while and see how you feel. And, if that’s completely out of the question for you, at least try to minimize it. You might find that lots of your mental stress mysteriously “disappears” as your caffeine intake goes down.

4. Attack Mental Stress Via the Back Door

That’s right: your body and mind are part of the whole being, and are constantly influencing and affecting each other. If you’re experiencing a lot of mental stress, try to reduce it by calming your body down—a calm body equals a calmer mind.

How do you calm your body down and reduce physical stress? A  great way to reduce physical stress (thereby reducing mental stress) is to take natural supplements that are proven to reduce stress and anxiety while lifting your mood. Three good ones to look into are kava-kava, St John’s wort, and rhodiola rosea:

  • Kava-kava is a natural plant known to have mild sedative properties, and you should be able to find it at your natural health food store or vitamin store. It’s available in capsules or liquid extract form.
  • St John’s wort is a natural flower used to treat depression. Again, it’s found at your local health store in capsules or liquid. Because it uplifts mood (enabling you to see the brighter side of all experiences) it helps relieve mental stress as well.
  • Rhodiola rosea is a natural plant shown to reduce stress and uplift mood, and Russian athletes have been using it forever. Like the other two supplements mentioned, rhodiola rosea can be found at your natural health store in capsule or liquid form.

While these supplements are all natural and can be very helpful for most people, always check with your health care provider first as they can cause side-effects depending on your current health situation etc.

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5. Good Old-Fashioned Exercise

This tip has been around forever because it works. Nothing relieves mental stress like running, kickboxing—you name it. Anything super-physical will wipe out most of your mental stresses once the exercise endorphins (happy chemicals) are released into your brain.

The result: mental stress will be gone!

So, if you’re feeling overwhelmed or just plain stressed, try using some of the above tips. You can even print this out or save it to refer to regularly.

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Featured photo credit: Radu Florin via unsplash.com

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